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Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.

Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.

Authors :
Ebadifar, Asghar
Ameli, Nazila
KhorramKhorshid, Hamid Reza
Kamali, Koorosh
Zeinabadi, Mehdi Salehi
Source :
Journal of Research in Medical Sciences. 2016, Vol. 21, p1-4. 4p.
Publication Year :
2016

Abstract

Background: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. Materials and Methods: Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed. Results: Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P > 0.05). Conclusion: Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17351995
Volume :
21
Database :
Academic Search Index
Journal :
Journal of Research in Medical Sciences
Publication Type :
Academic Journal
Accession number :
118099300