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Water-soluble derivatives of 4-oxo- N-(4-hydroxyphenyl) retinamide: synthesis and biological activity.
- Source :
-
Chemical Biology & Drug Design . Oct2016, Vol. 88 Issue 4, p608-614. 7p. - Publication Year :
- 2016
-
Abstract
- A novel series of 4-oxo- N-(4-hydroxyphenyl) retinamide (4-oxo-4- HPR) derivatives were synthesized with the aim of increasing the poor solubility of the parent compound in biological fluids, while maintaining the cytotoxic activity and the dual mechanism of action. The most promising compound 13a showed antiproliferative/apoptotic activity. The analysis of its mechanism of action revealed that it retained the particular characteristic of 4-oxo-4- HPR which is able to induce cell cycle arrest during the mitotic phase, coupled with the formation of aberrant mitotic spindles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17470277
- Volume :
- 88
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Chemical Biology & Drug Design
- Publication Type :
- Academic Journal
- Accession number :
- 118092685
- Full Text :
- https://doi.org/10.1111/cbdd.12781