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Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis.
- Source :
-
PLoS Genetics . 9/12/2016, Vol. 12 Issue 9, p1-18. 18p. - Publication Year :
- 2016
-
Abstract
- The phytohormone auxin is a key regulator of plant growth and development. Molecular studies in Arabidopsis have shown that auxin perception and signaling is mediated via TIR1/AFB–Aux/IAA co-receptors that assemble as part of the SCFTIR1/AFB E3 ubiquitin-ligase complex and direct the auxin-regulated degradation of Aux/IAA transcriptional repressors. Despite the importance of auxin signaling, little is known about the functional regulation of the TIR1/AFB receptor family. Here we show that TIR1 can oligomerize in planta via a set of spatially clustered amino acid residues. While none of the residues identified reside in the interaction interface of the TIR1-Aux/IAA degron, they nonetheless regulate the binding of TIR1 to Aux/IAA substrate proteins and their subsequent degradation in vivo as an essential aspect of auxin signaling. We propose oligomerization of TIR1 as a novel regulatory mechanism in the regulation of auxin-mediated plant patterning and development. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PLANT hormones
*AUXIN
*PLANT growth
*ARABIDOPSIS
*POLYMERIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 15537390
- Volume :
- 12
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- PLoS Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 118031525
- Full Text :
- https://doi.org/10.1371/journal.pgen.1006301