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A novel domino reaction for the preparation of substituted non-racemic β-proline derivatives.
- Source :
-
Tetrahedron . Oct2016, Vol. 72 Issue 40, p6011-6020. 10p. - Publication Year :
- 2016
-
Abstract
- A novel domino reaction for the preparation of non-racemic β-proline derivatives is reported. The addition of a methyl 2-(oxetan-3-yl)acetate titanium enolate to chiral tert -butanesulfinyl ketimines followed by an intramolecular oxetane ring-opening provides the highly-substituted pyrrolidine ring systems with three contiguous stereogenic centers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 72
- Issue :
- 40
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 118025327
- Full Text :
- https://doi.org/10.1016/j.tet.2016.08.017