hMSH6和P53在散发性结肠癌中的表达及意义.

Objective： To study expressions of hMSH6 and P53 in sporadic colorectal carcinoma (SCC) and their relation with SCC pathological features. Methods： Immunohistochemical Max-Vision two-step method was applied to detect the hMSH6 and P53 expression in 48 cases of SCC tumor tissue, adjacent tissue of 3-9 cm next to neoplastic loci and colon tissue of 10cm next to neoplastic loci, as well as that in 45 cases of normal colon tissue. Results： The positive expression rate of hMSH6 was lower in cancer tissues and adjacent tissues of 3-9 em next to neoplastic foci than in colon tissues of 10 cm next to neoplastic loci and normal colon tissues, while the positive expression rate of P53 was higher cancer tissues and adjacent tissues of 3-9cm next to neoplastic foci than in colon tissues of 10 cm next to neoplastic foci and normal colon tissues. The differences were statistically significant (P<0.05). hMSH6 expression was correlated with the loci location and depth of invasion (P<0.05). P53 positive expression was correlated with histological grade (P<0.05). The hMSH6 expression was negatively correlated with P53 (r=-0.403, P<0.05). Conclusion： The abnormal expression of hMSH6 and P53 involved in the process of occurrence and development of SCC. The hMSH6 and P53 can be used as evaluation indicators of SCC biological behavior. [ABSTRACT FROM AUTHOR]