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Rice bran prevents high-fat diet-induced inflammation and macrophage content in adipose tissue.
- Source :
-
European Journal of Nutrition . Sep2016, Vol. 55 Issue 6, p2011-2019. 9p. - Publication Year :
- 2016
-
Abstract
- Background: The inflammatory process associated with obesity mainly arises from white adipose tissue (WAT) alterations. In the last few years, nutritional-based strategies have been positioned as promising alternatives to pharmacological approaches against these pathologies. Our aim was to determine the potential of a rice bran enzymatic extract (RBEE)-supplemented diet in the prevention of metabolic, biochemical and functional adipose tissue and macrophage changes associated with a diet-induced obesity (DIO) in mice. Methods: C57BL/6J mice were fed high-fat diet (HF), 1 and 5 % RBEE-supplemented high-fat diet (HF1 % and HF5 %, respectively) and standard diet as control. Serum cardiometabolic parameters, adipocytes size and mRNA expression of pro-inflammatory biomarkers and macrophage polarization-related genes from WAT and liver were evaluated. Results: RBEE administration significantly decreased insulin resistance in obese mice. Serum triglycerides, total cholesterol, glucose, insulin, adiponectin and nitrites from treated mice were partially restored, mainly by 1 % RBEE-enriched diet. The incremented adipocytes size observed in HF group was reduced by RBEE treatment, being 1 % more effective than 5 % RBEE. Pro-inflammatory biomarkers in WAT such as IL-6 and IL-1β were significantly decreased in RBEE-treated mice. Adiponectin, PPARγ, TNF-α, Emr1 or M1/M2 levels were significantly restored in WAT from HF1 % compared to HF mice. Conclusions: RBEE-supplemented diet attenuated insulin resistance, dyslipidemia and morphological and functional alterations of adipose tissue in DIO mice. These benefits were accompanied by a modulating effect in adipocytes secretion and some biomarkers associated with macrophage polarization. Therefore, RBEE may be considered an alternative nutritional complement over metabolic syndrome and its complications. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD sugar analysis
*INFLAMMATION prevention
*LIVER analysis
*RNA analysis
*OBESITY complications
*GENES
*ADIPOSE tissues
*ANIMAL experimentation
*CHOLESTEROL
*FAT cells
*FAT content of food
*GLUCOSE tolerance tests
*HISTOLOGICAL techniques
*IMMUNOHISTOCHEMISTRY
*INSULIN
*INSULIN resistance
*INTERLEUKINS
*MACROPHAGES
*METABOLISM
*MICE
*NITRITES
*POLYMERASE chain reaction
*PROBABILITY theory
*RESEARCH funding
*RICE
*STATISTICS
*TRIGLYCERIDES
*TUMOR necrosis factors
*PLANT extracts
*DATA analysis
*STATISTICAL significance
*REVERSE transcriptase polymerase chain reaction
*DATA analysis software
*ADIPONECTIN
*PEROXISOME proliferator-activated receptors
*DESCRIPTIVE statistics
*ONE-way analysis of variance
*IN vivo studies
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 55
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 117807995
- Full Text :
- https://doi.org/10.1007/s00394-015-1015-x