Cold Contact Urticaria Following Vaccination: Four Cases.

The article describes the cases of patients who contracted cold contact urticaria (CCU) following vaccination with anti-Neisseria meningitides serogroup C conjugate vaccine. The patients experienced several symptoms including secondary generalized hives with malaise and pharyngeal discomfort, dizziness and oropharyngeal angiodema. A discussion on the link of CCU with cryoglobulinemia, oral contraceptive intake, angiotensin converting enzyme inhibitor and alprazolam is offered.