Back to Search
Start Over
Capacitive Detection of Morphine via Cathodically Electropolymerized, Molecularly Imprinted Poly( p-aminostyrene) Films.
- Source :
-
Macromolecular Chemistry & Physics . Aug2016, Vol. 217 Issue 16, p1810-1822. 13p. - Publication Year :
- 2016
-
Abstract
- Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly( p aminostyrene). Through molecular imprinting, morphine-specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20-40 × 10−6 m concentrations and a detection limit of 5.95 × 10−6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical-quartz crystal microbalance and characterized by X-ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen-bonding interactions between the monomer, cross-linker, and analyte form a stable pre-polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10221352
- Volume :
- 217
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Macromolecular Chemistry & Physics
- Publication Type :
- Academic Journal
- Accession number :
- 117510803
- Full Text :
- https://doi.org/10.1002/macp.201600127