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СУБСТРАТНА СПЕЦИФІЧНІСТЬ КАТЕПСИНУ Н НЕТРАНСФОРМОВАНОЇ ТКАНИНИ ТА ТКАНИНИ ПОМІРНО ДИФЕРЕНЦІЙОВАНОЇ ФОРМИ ІНФІЛЬТРУЮЧОГО ДОЛЬКОВОГО РАКУ МОЛОЧНОЇ ЗАЛОЗИ
- Source :
-
Bulletin of Taras Shevchenko National University of Kyiv / Vestnik Kievskogo Nacionalnogo Universiteta Imeni Tarasa Sevcenko . 2015, p50-52. 3p. - Publication Year :
- 2015
-
Abstract
- The substrate specifity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer has been investigated. Cathepsin H from untransformed tissues of mammary gland hydrolyzed synthetic substrates in a row: Bz-Gly-Phe--->Z-Phe-Ala--->Z-Glu- Tyr--->oxytocin unlike enzyme from malignant tumor that did not hydrolyze the synthetic dipeptide Z-Glu-Tyr and revealed the substrate specificity in a row: Z-Phe-Ala--->Bz-Gly-Phe--->oxytocin. Cathepsin H has proteolytic endopeptidase activity to the substrate casein more pronounced for enzyme from untransformed tissue of mammary gland. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Ukrainian
- ISSN :
- 17282748
- Database :
- Academic Search Index
- Journal :
- Bulletin of Taras Shevchenko National University of Kyiv / Vestnik Kievskogo Nacionalnogo Universiteta Imeni Tarasa Sevcenko
- Publication Type :
- Academic Journal
- Accession number :
- 117486537