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Chemical and in vitro biological information to predict mouse liver toxicity using recursive random forests.
- Source :
-
SAR & QSAR in Environmental Research . Jul2016, Vol. 27 Issue 7, p559-572. 14p. - Publication Year :
- 2016
-
Abstract
- In this study, recursive random forests were used to build classification models for mouse liver toxicity. The mouse liver toxicity endpoint (67 toxic and 166 non-toxic) was a composition of fourin vivochronic systemic and carcinogenic toxicity endpoints (non-proliferative, neoplastic, proliferative and gross pathology). A multiple under-sampling approach and a shifted classification threshold of 0.288 (non-toxic < 0.288 and toxic ≥ 0.288) were used to cope with the unbalanced data. Our study showed that recursive random forests are very efficient in variable selection and for the development of predictivein silicomodels. Generally, over 95% redundant descriptors could be reduced from modelling for all the chemical, biological and hybrid models in this study. The predictive performance of chemical models (CCR of 0.73) is comparable with hybrid model performance (CCR of 0.74). Descriptors related to the octanol–water partition coefficient are vital for model performance. Thein vitroendpoint of CYP2A2 played a key role in the development and interpretation of hybrid models. Identifying high-throughput screening assays relevant to liver toxicity would be key for improvingin silicomodels of liver toxicity. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 1062936X
- Volume :
- 27
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- SAR & QSAR in Environmental Research
- Publication Type :
- Academic Journal
- Accession number :
- 117485021
- Full Text :
- https://doi.org/10.1080/1062936X.2016.1201142