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Histopathologic and mutational analysis of a case of blue nevus-like melanoma.
- Source :
-
Journal of Cutaneous Pathology . Sep2016, Vol. 43 Issue 9, p776-780. 5p. - Publication Year :
- 2016
-
Abstract
- Blue nevi are a heterogeneous group of dermal melanocytic proliferations that share a common clinical appearance but remain controversial in their histopathologic and biologic distinction. While common blue nevi and cellular blue nevi are well-defined entities that are classified without significant controversy, the distinction between atypical cellular blue nevi and blue nevus-like melanoma remains diagnostically challenging. We report a case of a 46-year-old female with recurrent blue nevus-like melanoma of the scalp with liver metastases; mutational analysis showed GNA11 Q209L and BAP1 Q393 mutations. To our knowledge, this is the first case of blue nevus-like melanoma with GNA11 and BAP1 mutations. These particular mutations and the predilection for liver metastases in our patient's case underscore a fundamental biological relationship between blue nevi and uveal melanoma and suggest the two entities may prove amenable to similar diagnostic and prognostic testing and targeted therapies [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIVER metastasis
*GENETIC mutation
*UVEAL diseases
*PHENOTYPES
SCALP tumors
Subjects
Details
- Language :
- English
- ISSN :
- 03036987
- Volume :
- 43
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Cutaneous Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 117449989
- Full Text :
- https://doi.org/10.1111/cup.12731