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تهیه و ارزیابی ویژگی لیپوزومهای اشریشیاکلی به عنوان یک سیستم دارو رسانی نوین به سلولهای سرطانی کولون
- Source :
-
Biological Journal of Microorganism . Spring2016, Vol. 5 Issue 17, p87-8. 10p. - Publication Year :
- 2016
-
Abstract
- Introduction: Liposomes are spherical vesicles composed of concentric phospholipid bilayers that can entrap hydrophilic, hydrophobic drugs. Liposomes can be prepared from natural phospholipids, synthetic lipids or bacterial lipids. The aim of this study was to formulate liposome from bacterial lipids and evaluate physicochemical properties. Materials and methods: This study was performed experimentally on E.coli. The lipids were extracted from E.coli. using chloroform and methanol. Film method was used for preparing nano-systems and methylene blue was used as a drug model. Then their particle sizes were determined using particle sizer. The release methylene blue was carried out using dialysis membrane. Also, trailing them in cancer cells was evaluated by using carboxyfluorescein. Results: The average particle size of E.coli. liposomal was 338 nm. Encapsulation efficiency was 53.33 ± 2.88% and the value of release after 24 h was 97.54% ± 0.00. Liposomes could deliver the carboxyfluorescein to cancer cells. Discussion and conclusion: The results of this study demonstrated that bacterial liposome has probably a suitable nano-particle such as particle size and desirable loading and it is possible to use them as drug delivery system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Persian
- ISSN :
- 23225173
- Volume :
- 5
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Biological Journal of Microorganism
- Publication Type :
- Academic Journal
- Accession number :
- 117448936