Back to Search Start Over

Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue.

Authors :
Park, Ye Seul
Uddin, Md Jamal
Piao, Lingjuan
Hwang, Inah
Lee, Jung Hwa
Ha, Hunjoo
Source :
Mediators of Inflammation. 8/15/2016, p1-14. 14p.
Publication Year :
2016

Abstract

Macrophages are important components of adipose tissue inflammation, which results in metabolic diseases such as insulin resistance. Notably, obesity induces a proinflammatory phenotypic switch in adipose tissue macrophages, and oxidative stress facilitates this switch. Thus, we examined the role of endogenous catalase, a key regulator of oxidative stress, in the activity of adipose tissue macrophages in obese mice. Catalase knockout (CKO) exacerbated insulin resistance, amplified oxidative stress, and accelerated macrophage infiltration into epididymal white adipose tissue in mice on normal or high-fat diet. Interestingly, catalase deficiency also enhanced classical macrophage activation (M1) and inflammation but suppressed alternative activation (M2) regardless of diet. Similarly, pharmacological inhibition of catalase activity using 3-aminotriazole induced the same phenotypic switch and inflammatory response in RAW264.7 macrophages. Finally, the same phenotypic switch and inflammatory responses were observed in primary bone marrow-derived macrophages from CKO mice. Taken together, the data indicate that endogenous catalase regulates the polarization of adipose tissue macrophages and thereby inhibits inflammation and insulin resistance. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09629351
Database :
Academic Search Index
Journal :
Mediators of Inflammation
Publication Type :
Academic Journal
Accession number :
117447370
Full Text :
https://doi.org/10.1155/2016/8675905