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Protein sequence analysis by incorporating modified chaos game and physicochemical properties into Chou's general pseudo amino acid composition.
- Source :
-
Journal of Theoretical Biology . Oct2016, Vol. 406, p105-115. 11p. - Publication Year :
- 2016
-
Abstract
- In this contribution we introduced a novel graphical method to compare protein sequences. By mapping a protein sequence into 3D space based on codons and physicochemical properties of 20 amino acids, we are able to get a unique P -vector from the 3D curve. This approach is consistent with wobble theory of amino acids. We compute the distance between sequences by their P -vectors to measure similarities/dissimilarities among protein sequences. Finally, we use our method to analyze four datasets and get better results compared with previous approaches. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00225193
- Volume :
- 406
- Database :
- Academic Search Index
- Journal :
- Journal of Theoretical Biology
- Publication Type :
- Academic Journal
- Accession number :
- 117442631
- Full Text :
- https://doi.org/10.1016/j.jtbi.2016.06.034