Similarities and differences between mast cells and basophil.

Human mast cells and basophils are hematopoietic stem cell-derived elements with quite similar morphological features. Their differentiation pathways are under the control of different cytokines, namely Stem Cell Factor for mast cells and Interleukin-3 for basophils. While mast cells are tissue-resident elements, basophils are found exclusively in the bloodstream. In contrast to basophils, mast cells are heterogeneous in morphology and function, depending on their tissue location. Because both cell types express the high affinity receptor for IgE, they can play a critical role in IgE-dependent allergic reactions. Nevertheless, when activated through this receptor, they release somewhat different panels of mediators. In addition, both of these cell types, but particularly mast cells, can also play a role in innate immunity. Through the various mediators they release, they are able to control various adaptive responses of the immune system. [Copyright &y& Elsevier]