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Diversity of the muscarinic and nicotinic responses of subfornical organ neurons in rat slice preparations
- Source :
-
Neuroscience Letters . Jan2004, Vol. 354 Issue 2, p135. 4p. - Publication Year :
- 2004
-
Abstract
- Recently we found that subfornical organ (SFO) neurons were activated through nicotinic receptors as well as muscarinc. In this study, the preferential responses of single SFO neurons to both muscarine and nicotine were examined by using rat slice preparations, and current and voltage clamp recordings. When the amplitudes of the depolarizations and inward currents by muscarine and nicotine in single SFO neurons were compared, some neurons showed a higher sensitivity to muscarine than to nicotine while others showed vice versa. These data indicate that acetylcholine activates SFO neurons preferentially through either muscarinic or nicotinic receptors and suggest a diversity of cholinergic responses in the SFO. [Copyright &y& Elsevier]
- Subjects :
- *NEURONS
*MUSCARINE
*CARDIOVASCULAR diseases
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 354
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 11732427
- Full Text :
- https://doi.org/10.1016/j.neulet.2003.10.007