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Lewis Acid Catalyzed Cyclization of Propargylic Alcohols with 2-Vinylphenol.
- Source :
-
Organic Letters . Aug2016, Vol. 18 Issue 15, p3866-3869. 4p. - Publication Year :
- 2016
-
Abstract
- An unprecedented Lewis acid catalyzed, protection-free, and high-efficiency synthesis of valuable 3,4-dihydro-2H-2,4-methanochromans via cycloaddition of propargylic alkynols with 2-vinylphenol is described. This cycloaddition protocol, which tolerates a wide variety of functional groups, provides practical, versatile, and atom-economical access to a new class of appealing bridged-ring products in satisfactory yields. Compared with the reported reaction conditions for bridged-ring skeletons synthesis, the present reaction conditions are neutral, mild, and without any additives. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 18
- Issue :
- 15
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 117301056
- Full Text :
- https://doi.org/10.1021/acs.orglett.6b01875