Novel technique to relax the lower esophageal sphincter during challenging peroral endoscopic myotomy (POEM).

The article presents several case studies related to the effect of amyl nitrite on lower esophageal sphincter relaxation (LES) during peroral endoscopic myotomy (POEM). It presents a case 59-year-old man who underwent POEM for type III achalasia and a 38-year-old woman who underwent POEM for type II achalasia. It highlights that administration increases heart rate of patient. It informs that amyl nitrite is a safe method to relax LES for creation of a submucosal tunnel to avoid mucosal injury.