Impact of Donor Arterial Partial Pressure of Oxygen on Outcomes After Lung Transplantation in Adult Cystic Fibrosis Recipients.

Introduction: Donor PO levels are used for assessing organs for lung transplantation (LTx), but survival implications of PO levels in adult cystic fibrosis (CF) patients receiving LTx are unclear. Methods: UNOS registry data spanning 2005-2013 were used to test for associations of donor PO with patient survival and bronchiolitis obliterans syndrome (BOS) in adult (age ≥ 18 years) first-time LTx recipients diagnosed with CF. Results: The analysis included 1587 patients, of whom 1420 had complete data for multivariable Cox models. No statistically significant differences among donor PO categories of ≤200, 201-300, 301-400, or >400 mmHg were found in univariate survival analysis (log-rank test p = 0.290). BOS onset did not significantly differ across donor PO categories (Chi-square p = 0.480). Multivariable Cox models of patient survival supported the lack of difference across donor PO categories. Interaction analysis found a modest difference in survival between the two top categories of donor PO when examining patients with body mass index (BMI) in the lowest decile (≤16.5 kg/m). Conclusions: Donor PO was not associated with survival or BOS onset in adult CF patients undergoing LTx. Notwithstanding statistically significant interactions between donor PO and BMI, there was no evidence of post-LTx survival risk associated with donor PO below conventional thresholds in any subgroup of adults with CF. [ABSTRACT FROM AUTHOR]