利奈唑胺对肾功能不全 G+感染患者血小板减少的相关性研究.

Objective: To analyze the relationship of renal dysfunction and linezolid-induced thrombocytopenia. Methods: A retrospective analysis was performed on the clinical data of 92 cases of linezolid-treated patients with Gram-positive bacterial infections. 33 patients with renal dysfunction were designed into the renal dysfunction group, and 59 other patients were assigned as normal group. Detected the platelet before and after treatment, and observe the time for platelet count recovering to normal after treatment and the occurrence of adverse reactions. Results: After treatment, platelet count of renal dysfunction group was significantly lower than before treatment and normal group (P<0.01). There was no statistical difference in platelet count between before and after treatment in the normal group (P>0.05). In renal dysfunction group, the incidence of thrombocytopenia was higher than in the normal group(P<0.05). After treatment, the normal group took shorter time to have the platelet recovered than the renal dysfunction group(P<0.01). Hemoglobin decreased greater in renal dysfunction group than in the normal group (P<0.05). The other incidences of adverse reactions showed no significant differences (P>0.05). Conclusion: The kidney function of infected patients can affect their linezolid-induced thrombocytopenia. Patients with renal dysfunction should have regular monitor on platelet counts when taking linezolid. [ABSTRACT FROM AUTHOR]