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Body surface area as a prognostic marker in chronic heart failure patients: results from the Heart Failure Registry of the Heart Failure Association of the European Society of Cardiology.
- Source :
-
European Journal of Heart Failure . Jul2016, Vol. 18 Issue 7, p859-868. 10p. 5 Charts, 2 Graphs. - Publication Year :
- 2016
-
Abstract
- <bold>Aims: </bold>The 'obesity paradox' is consistently observed in patients with heart failure (HF). We investigated the relationship of body surface area (BSA) to mortality and hospitalizations in patients with chronic HF.<bold>Methods and Results: </bold>Data from the outpatient cohort of the observational, prospective, Heart Failure Long-Term Registry of the Heart Failure Association of the European Society of Cardiology was analysed in order to evaluate the prognostic significance of BSA in chronic HF. A total of 9104 chronic HF patients (age 64.8 ± 13.4 years; 71.6% males) were enrolled. Mortality during 1-year follow-up was observed in 718 of 8875 (8.1%) patients. A progressive, inverse relationship between all-cause mortality and BSA levels was observed; the adjusted hazard ratio (HR) for 1-year mortality was 1.823 [95% confidence interval (CI) 1.398-2.376], P < 0.001 for the lowest quartile of BSA <1.78 m(2) , and 1.255, 95% CI 1.000-1.576, P = 0.05 for the middle two quartiles (1.78 ≤BSA ≤2.07 m(2) ), compared with the highest quartile (BSA >2.07 m(2) ). For each increase of 0.1 m(2) in BSA, an adjusted HR of 0.908 (95% CI 0.870-0.948), P < 0.001 for mortality was calculated. HF hospitalizations were not associated with BSA subgroup distribution. In both genders, subjects within the lowest BSA quartile (males <1.84 m(2) and females <1.64 m(2) ) had significantly higher mortality rates during follow-up (log-rank P < 0.0001). However, the stepwise association with mortality was more distinct in males.<bold>Conclusions: </bold>Total and cardiovascular mortality, but not HF hospitalizations was inversely associated with BSA levels in chronic HF patients. BSA may serve as a prognostic indicator for adverse outcome in HF patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEART failure patients
*BODY surface area
*BIOMARKERS
*MEDICAL registries
*HEART failure treatment
*TAKOTSUBO cardiomyopathy
*CARDIOLOGY
*CHRONIC diseases
*CAUSES of death
*HEART failure
*HOSPITAL care
*LONGITUDINAL method
*MEDICAL societies
*MORTALITY
*MULTIVARIATE analysis
*OBESITY
*PROGNOSIS
*SEX distribution
*COMORBIDITY
*ACQUISITION of data
*PROPORTIONAL hazards models
CARDIOVASCULAR disease related mortality
Subjects
Details
- Language :
- English
- ISSN :
- 13889842
- Volume :
- 18
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- European Journal of Heart Failure
- Publication Type :
- Academic Journal
- Accession number :
- 116858231
- Full Text :
- https://doi.org/10.1002/ejhf.551