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Association of the microsatellite (GT) n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma.
- Source :
-
Acta Oto-Laryngologica . Aug2016, Vol. 136 Issue 8, p806-811. 6p. - Publication Year :
- 2016
-
Abstract
- Conclusion: Long (GT)nrepeat polymorphisms in the heme oxygenase-1 (HO-1) gene promoter and decreased serum HO-1 levels are associated with a higher susceptibility to laryngeal squamous cell carcinoma (LSCC).Objective: In this case-control study, the association of HO-1 microsatellite (GT)nrepeat polymorphisms and serum levels with the risk of LSCC was investigated.Methods: A total of 142 LSCC patients, 54 vocal leukoplakia patients and 98 healthy controls, were examined for (GT)npolymorphisms by sequencing, and the serum HO-1 levels were detected in a sub-set from participants above by ELISA.Results: Compared with the controls, the LSCC group had significantly higher frequencies of L-allele (> 29 repeats) and L-allele carriers (p < 0.001, OR = 2.037 andp = 0.005, OR = 2.152, respectively). The frequencies of lymph node metastasis and of moderate or poor differentiation were significantly higher in L-allele carriers compared to non-L-allele carriers (p < 0.05). Significantly lower serum HO-1 levels were detected in LSCC patients (p < 0.001), and patients with lower serum HO-1 levels had more advanced cancer stage and a higher lymph node metastasis rate (p < 0.05). Furthermore, the L-allele carriers had lower serum HO-1 concentrations compared with the non-L-allele carriers (p = 0.019). [ABSTRACT FROM PUBLISHER]
- Subjects :
- *ANALYSIS of variance
*CHI-squared test
*CONFIDENCE intervals
*DISEASE susceptibility
*FISHER exact test
*GENETIC polymorphisms
*LEUKOPLAKIA
*OXIDOREDUCTASES
*POLYMERASE chain reaction
*PROBABILITY theory
*RESEARCH funding
*T-test (Statistics)
*CASE-control method
*SQUAMOUS cell carcinoma
*DATA analysis software
*ODDS ratio
*MANN Whitney U Test
*GENOTYPES
*KRUSKAL-Wallis Test
*GENETICS
*TUMOR risk factors
*CANCER risk factors
LARYNGEAL tumors
Subjects
Details
- Language :
- English
- ISSN :
- 00016489
- Volume :
- 136
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Acta Oto-Laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 116750458
- Full Text :
- https://doi.org/10.3109/00016489.2016.1157265