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Cilostazol Enhances Mobilization of Circulating Endothelial Progenitor Cells and Improves Endothelium-Dependent Function in Patients at High Risk of Cardiovascular Disease.
- Source :
-
Angiology . Aug2016, Vol. 67 Issue 7, p638-646. 9p. - Publication Year :
- 2016
-
Abstract
- This is the first study to investigate the vasculoangiogenic effects of cilostazol on endothelial progenitor cells (EPCs) and flow-mediated dilatation (FMD) in patients at high risk of cardiovascular disease (CVD). This double-blind, placebo-controlled study included 71 patients (37 received 200 mg/d cilostazol and 34 received placebo for 12 weeks). Use of cilostazol, but not placebo, significantly increased circulating EPC (kinase insert domain receptor+CD34+) counts (percentage changes: 149.0% [67.9%-497.8%] vs 71.9% [−31.8% to 236.5%], P = .024) and improved triglyceride and high-density lipoprotein cholesterol levels (P = .002 and P = .003, respectively). Plasma levels of vascular endothelial growth factor (VEGF)-A165 and FMD significantly increased (72.5% [32.9%-120.4%] vs −5.8% [−46.0% to 57.6%], P = .001; 232.8% ± 83.1% vs −46.9% ± 21.5%, P = .003, respectively) in cilostazol-treated patients. Changes in the plasma triglyceride levels significantly inversely correlated with the changes in the VEGF-A165 levels and FMD. Cilostazol significantly enhanced the mobilization of EPCs and improved endothelium-dependent function by modifying some metabolic and angiogenic markers in patients at high risk of CVD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARDIOVASCULAR diseases risk factors
*STATISTICAL correlation
*ENDOTHELIUM
*EPITHELIAL cells
*LONGITUDINAL method
*NEOVASCULARIZATION
*RESEARCH funding
*STATISTICS
*STEM cells
*T-test (Statistics)
*TRIGLYCERIDES
*TETRAZOLES
*DATA analysis
*VASCULAR endothelial growth factors
*RANDOMIZED controlled trials
*BLIND experiment
*DATA analysis software
*DESCRIPTIVE statistics
*MANN Whitney U Test
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 67
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 116734341
- Full Text :
- https://doi.org/10.1177/0003319715606249