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Diet Quality and Colorectal Cancer Risk in the Women's Health Initiative Observational Study.
- Source :
-
American Journal of Epidemiology . 7/1/2016, Vol. 184 Issue 1, p23-32. 10p. - Publication Year :
- 2016
-
Abstract
- Diet quality index scores on Healthy Eating Index 2010 (HEI-2010), Alternative HEI-2010, alternative Mediterranean Diet Index, and the Dietary Approaches to Stop Hypertension (DASH) index have been inversely associated with all cause and cancer-specific death. This study assessed the association between these scores and colorectal cancer (CRC) incidence as well as CRC-specific mortality in the Women's Health Initiative Observational Study (1993-2012), a US study of postmenopausal women. During an average of 12.4 years of follow-up, there were 938 cases of CRC and 238 CRC-specific deaths. We estimated multivariate hazard ratios and 95% confidence intervals for relationships between quintiles of diet scores (from baseline food frequency questionnaires) and outcomes. HEI-2010 score (hazard ratios were 0.81, 0.77, and 0.73 with P values of 0.04, 0.01, and <0.01 for quintiles 3-5 vs. quintile 1, respectively) and DASH score (hazard ratios were 0.72, 0.74, and 0.78 with P values of <0.01, <0.01, and 0.03 for quintiles 3-5 vs. quintile 1, respectively), but not other diet scores, were associated with a lower risk of CRC in adjusted models. No diet scores were significantly associated with CRC-specific mortality. Closer adherence to HEI-2010 and DASH dietary recommendations was inversely associated with risk of CRC in this large cohort of postmenopausal women. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTHROPOMETRY
*CANCER patients
*COLON tumors
*CONFIDENCE intervals
*STATISTICAL correlation
*DIET
*ENERGY metabolism
*FOOD
*HORMONE therapy
*LONGITUDINAL method
*MEDICAL cooperation
*NUTRITIONAL requirements
*PROBABILITY theory
*QUESTIONNAIRES
*RESEARCH
*RESEARCH funding
*SMOKING
*STATISTICAL hypothesis testing
*WOMEN'S health
*SOCIOECONOMIC factors
*BODY mass index
*FOOD Pyramid
*PROPORTIONAL hazards models
*POSTMENOPAUSE
*FOOD diaries
*PHYSICAL activity
*DATA analysis software
*MEDITERRANEAN diet
*DASH diet
RECTUM tumors
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 184
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 116593898
- Full Text :
- https://doi.org/10.1093/aje/kwv304