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Associations Between Maternal Pregravid Obesity and Gestational Diabetes and the Timing of Pubarche in Daughters.
- Source :
-
American Journal of Epidemiology . 7/1/2016, Vol. 184 Issue 1, p7-14. 8p. - Publication Year :
- 2016
-
Abstract
- We investigated whether in utero exposure to maternal pregravid obesity and/or gestational diabetes mellitus (GDM) was associated with early puberty in girls. We used data from a longitudinal study of 421 mother-daughter pairs enrolled in an integrated health services organization, Kaiser Permanente Northern California (2005-2012). Girls aged 6-8 years were followed annually through ages 12-14 years. Onset of puberty was assessed using study clinic-based Tanner staging. We examined associations of self-reported pregravid obesity and maternal GDM with timing of the daughter's transition to pubertal maturation stage 2 or above for development of breasts and pubic hair, using accelerated failure time regression models with interval censoring to estimate time ratios and hazard ratios and corresponding 95% confidence intervals. Maternal obesity (pregravid body mass index (BMI; weight (kg)/ height (m)²) ≥30) was associated with a daughter's earlier transition to breast and pubic hair stage 2+ in comparison with girls whose mothers had pregravid BMI <25. These associations were attenuated and not statistically significant after adjustment for covariates. Girls whose mothers had both pregravid BMI ≥25 and GDM were at higher risk of an earlier transition to pubic hair stage 2+ than those whose mothers had neither condition (adjusted time ratio = 0.89, 95% confidence interval: 0.83, 0.96; hazard ratio = 2.97, 95% confidence interval: 1.52, 5.83). These findings suggest that exposure to maternal obesity and hyperglycemia places girls at higher risk of earlier pubarche. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PRECOCIOUS puberty
*AGE factors in disease
*ANALYSIS of variance
*BIRTH weight
*BODY composition
*CHI-squared test
*CONFIDENCE intervals
*DAUGHTERS
*GESTATIONAL diabetes
*EPIDEMIOLOGICAL research
*ETHNIC groups
*HEALTH maintenance organizations
*INTERVIEWING
*LONGITUDINAL method
*MOTHERS
*OBESITY
*PROBABILITY theory
*PUBERTY
*REGRESSION analysis
*RESEARCH funding
*SELF-evaluation
*SURVIVAL analysis (Biometry)
*SOCIOECONOMIC factors
*BODY mass index
*DATA analysis software
*DESCRIPTIVE statistics
*PRENATAL exposure delayed effects
*CHILDREN
*PREGNANCY
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 184
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 116593892
- Full Text :
- https://doi.org/10.1093/aje/kww006