Drug Delivery: The Application of Stimuli-Responsive VEGF- and ATP-Aptamer-Based Microcapsules for the Controlled Release of an Anticancer Drug, and the Selective Targeted Cytotoxicity toward Cancer Cells (Adv. Funct. Mater. 24/2016).

Adenosine triphosphate (ATP)–responsive DNA‐based microcapsules loaded with the chemotherapeutic doxorubicin drug are synthesized and incorporated into cancer cells. I. Willner and co‐workers find, on page 4262, that over‐expressed ATP in cancer cells dissociates the microcapsules and releases the drug, resulting in selective cytotoxicity toward cancer cells. [ABSTRACT FROM AUTHOR]