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Highly functionalized dispiro oxindole-pyrrolo[1,2-c]thiazole-piperidone hybrid: Synthesis, characterization and theoretical investigations on the regiochemistry.
- Source :
-
Journal of Molecular Structure . Oct2016, Vol. 1121, p93-103. 11p. - Publication Year :
- 2016
-
Abstract
- The synthesis of highly functionalized dispiro oxindole–pyrrolo[1,2- c ]thiazole–piperidone hybrid has been achieved regioselectively employing microwave-assisted three-component 1,3-dipolar cycloaddition. Structural elucidation of the compound has been accomplished using NMR spectroscopy and further confirmed by single crystal X-ray crystallographic studies. The molecular structure of the compound crystallized in monoclinic, P 2 1 / c , a = 11.6182 (2) Å, b = 12.2466 (2) Å, c = 21.7061 (3) Å, β = 103.018 (1)°, V = 3009.04 (8) Å 3 , Z = 4. The cycloaddition was found to proceed by normal electronic demand (NED) character with a significant high charge transfer (0.1247 eV) from the 1,3-dipole to the dipolarophile. The regiochemistry has been explained using the local reactivity descriptors obtained from the DFT calculations. The DFT optimized molecular structure agreed well with the X-ray results. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OXINDOLES
*THIAZOLES
*PIPERIDONES
*ZWITTERIONS
*SINGLE crystals
Subjects
Details
- Language :
- English
- ISSN :
- 00222860
- Volume :
- 1121
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Structure
- Publication Type :
- Academic Journal
- Accession number :
- 116277680
- Full Text :
- https://doi.org/10.1016/j.molstruc.2016.05.061