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Polydopamine-coated liposomes as pH-sensitive anticancer drug carriers.
- Source :
-
Journal of Microencapsulation . May2016, Vol. 33 Issue 3, p257-262. 6p. - Publication Year :
- 2016
-
Abstract
- Stimuli-responsive drug carriers are considered to play important roles in chemotherapy. We fabricated pH-sensitive polydopamine-protected liposomes (liposome@PDA) drug delivery systems, which were characterised with microscope, scanning electron microscope (SEM), UV-vis spectrometer and Fourier transform infrared (FTIR) technieques. The typical chemotherapeutic agent, 5-fluorouracil (5-FU), was loaded into liposome@PDA capsules. The maximum release percentages of 5-FU are 3.2%, 29.5%, 52.7%, 76.7% in the solution with pH 7.42, 6.87, 4.11 and 3.16, respectively. Thein vitrocell cytotoxity experiments were carried out using 5-FU-loaded capsules at pH 6.87 solution, which simulate the true pH around cancerous cells. At 1.5 μM concentration, the free 5-FU, 5-FU-loaded liposome capsules and 5-FU-loaded capsules showed the cell viability of 50.56%, 22.66% and 21.63%, respectively. It confirms that drug-loaded capsules performed better than free drug. The results demonstrate the great potential of liposome@PDA capsules as carriers in biomedical applications. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 02652048
- Volume :
- 33
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Microencapsulation
- Publication Type :
- Academic Journal
- Accession number :
- 116265312
- Full Text :
- https://doi.org/10.3109/02652048.2016.1156176