Back to Search
Start Over
Visceral fat obesity increases serum DPP-4 levels in men with type 2 diabetes mellitus.
- Source :
-
Diabetes Research & Clinical Practice . Jun2016, Vol. 116, p1-6. 6p. - Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>The relationship between serum DPP-4 level and visceral fat mass is still unclear in type 2 diabetes mellitus (T2DM). This study thus aimed to examine the association of visceral fat accumulation and metabolic syndrome with serum DPP-4 levels in T2DM. <bold>Methods: </bold>Visceral and subcutaneous fat areas were evaluated by performing computed tomography scan in 135 men with T2DM, who had never taken DPP-4 inhibitors or GLP-1 receptor agonists. We investigated the association between serum DPP-4 levels and visceral fat area as well as the presence of metabolic syndrome. <bold>Results: </bold>Multiple regression analysis adjusted for age, duration of T2DM, body mass index, serum creatinine, and HbA1c showed that serum DPP-4 levels were positively associated with visceral fat area (β=0.25, p=0.04), but not subcutaneous fat area (β=-0.18, p=0.13). In logistic regression analyses adjusted for the confounding factors described above, serum DPP-4 levels were positively associated with visceral fat obesity and metabolic syndrome [odds ratio (OR)=1.63, 95% confidence interval (CI)=1.00-2.66 per standard deviation (SD) increase, p=0.04; OR=1.77, 95%CI=1.09-2.88 per SD increase, p=0.02, respectively]. <bold>Conclusions: </bold>The present study showed that serum DPP-4 level was positively and specifically associated with accumulation of visceral fat and the presence of metabolic syndrome in men with T2DM. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEOPLE with diabetes
*METABOLIC syndrome
*OBESITY
*CD26 antigen
*COMPUTED tomography
*DIAGNOSIS
*TYPE 2 diabetes complications
*OBESITY complications
*ADIPOSE tissues
*ANTHROPOMETRY
*MULTIVARIATE analysis
*TYPE 2 diabetes
*PROTEOLYTIC enzymes
*LOGISTIC regression analysis
*CROSS-sectional method
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 116
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 116220847
- Full Text :
- https://doi.org/10.1016/j.diabres.2016.04.027