自然杀伤细胞对妊娠期糖尿病患者并发高脂血症的影响.

Objective: To observe the effect of Natural killer cells on hyperlipidemia of patients with gestational diabetes. Methods: A total of 95 gestational diabetes patients with hyperlipidemia, confirmed in Affiliated Hospital of Qiingdao University during February 2013 to April 2015, were chosen as research group; 100 healthy pregnant women from a medical physical examination, as control group at the same time. The levels of blood glucose, glycosylated hemoglobin, body mass index,total cholesterol, triglycerides, low density lipoprotein cholesterol, high density lipoprotein cholesterol, interleukin-2, IL-6, interferon-gamma, NK cells and the cell subtype were compared between the two groups. The correlation of NK cells with blood fat was analyzed by the Person correlation analysis. Results: (1) The levels of fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, BMI in the research group were signifi- cantly higher than those in the control group, the differences were statistically significant (P<0.05); (2) The levels of TC, TG, LDL -C in the research group were significantly higher than those in the control group, the level of HDL-C was significantly lower than that of the control group, the differences were statistically significant (P<0.05); (3) The levels of IL-2, IFN-γin the research group were significant- ly lower than those in the control group, with statistically significant differences (P<0.05); the level of IL-6 in the research group was sig- nificantly higher than that in the control group, with statistically significant differences (P<0.05); (4)The number of NK cells, CD4+/CD3+, CD4+/CD8+ CD56++CD4+/CD3+ in the research group were lower than those in the control group (P<0.05); CD8+/CD3+, CD18+/CD8+, CD19+/CD3+ were higher than those in the control group (P<0.05), there was no statistical significance in CD28+/CD8+ between the two groups (P>0.05). (5) NK cell count was negatively correlated with the levels of TC, TG, LDL-C (r=-0.527, -0.598, -0.485), positively correlated with HDL-C (r=0.528). Conclusion: The number of NK cells in the pregnant women with gestational diabetes declines, their activity also reduces, which might be correlated with change of different phenotypes of NK cells participating in the body's immune response, leading to blood lipid regulation imbalance and the process of hyperlipemia. [ABSTRACT FROM AUTHOR]