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Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans
- Source :
-
American Journal of Cardiology . Dec2003, Vol. 92 Issue 12, p1487-1490. 4p. - Publication Year :
- 2003
-
Abstract
- Seventy-nine African-American participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) pilot study were genotyped for the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and had spectral power of their high-frequency (HF) heart rate variability (HRV) determined by fast-Fourier transformation. HF HRV was highest in II, intermediate in ID, and lowest in DD (II vs DD, p <0.043) genotypes, thus making an association of the ACE I/D DD genotype with decreased HF HRV that is consistent with the hypothesis that the DD genotype confers susceptibility to increased cardiovascular risk. The urban African-American population we studied had a particularly high cardiovascular risk, and these findings suggest that ACE I/D genotypes may modify that risk. [Copyright &y& Elsevier]
- Subjects :
- *ANGIOTENSINS
*ENZYMES
*CARDIOVASCULAR system
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 00029149
- Volume :
- 92
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- American Journal of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 11608966
- Full Text :
- https://doi.org/10.1016/j.amjcard.2003.08.069