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Effect of coadministration of ezetimibe and simvastatin on high-sensitivity C-reactive protein
- Source :
-
American Journal of Cardiology . Dec2003, Vol. 92 Issue 12, p1414. 5p. - Publication Year :
- 2003
-
Abstract
- This study assessed the effect of ezetimibe coadministered with simvastatin on high-sensitivity C-reactive protein (hs-CRP) in patients with primary hypercholesterolemia. After dietary stabilization, a 2- to 12-week washout period, and a 4-week, single-blind, placebo lead-in period, patients with baseline low-density lipoprotein cholesterol ≥145 and ≤250 mg/dl and triglycerides ≤350 mg/dl were randomized to one of these daily treatments for 12 consecutive weeks: ezetimibe 10 mg; simvastatin monotherapy (10, 20, 40, or 80 mg); ezetimibe 10 mg plus simvastatin (10, 20, 40, or 80 mg); or placebo. The primary analysis was the change in hs-CRP for the pooled ezetimibe plus simvastatin versus simvastatin monotherapy groups. Ezetimibe plus simvastatin significantly reduced median hs-CRP levels compared with simvastatin monotherapy (−34.8% vs −18.2%, p< 0.01), and incremental reductions were observed at each simvastatin dose level. Combination therapy-induced significant changes in individual lipid parameters did not explain the observed decreases in hs-CRP. Thus, ezetimibe coadministered with simvastatin resulted in significant incremental decreases in hs-CRP, possibly consistent with an additional anti-inflammatory effect compared with simvastatin monotherapy. [Copyright &y& Elsevier]
- Subjects :
- *C-reactive protein
*HYPERCHOLESTEREMIA
*ANTI-inflammatory agents
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 00029149
- Volume :
- 92
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- American Journal of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 11608945
- Full Text :
- https://doi.org/10.1016/j.amjcard.2003.08.048