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Binding of antibodies to human immunodeficiency virus type 1 (HIV-1)-infected lymphocytes elicited by vaccines and by natural infection
- Source :
-
Vaccine . Jan2004, Vol. 22 Issue 3/4, p383. 15p. - Publication Year :
- 2004
-
Abstract
- Binding of antibodies to oligomeric envelope glycoprotein of R5-tropic primary isolates of human immunodeficiency virus type 1 (HIV-1) was studied by flow cytometry using sera from HIV-1 vaccine recipients and clade B and C HIV-1-infected patients, and monoclonal and polyclonal antibodies to neutralizing epitopes of HIV-1. Vaccine recipients received recombinant canarypox virus vaccine expressing HIV-1 gene products, and SF-2 recombinant gp120 subunit vaccine. Anti-gp120 neutralizing antibodies including human monoclonal antibody 2G12 and goat polyclonal anti-serum to V3 loop peptide [peptide T1-SP10MN(A)] bound to HIV-1-infected cells. Sera from vaccine recipients bound to HIV-1-infected cells, but at levels lower than did infected patient sera. [Copyright &y& Elsevier]
- Subjects :
- *IMMUNOGLOBULINS
*OLIGOMERS
*GLYCOPROTEINS
*FLOW cytometry
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Volume :
- 22
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 11606350
- Full Text :
- https://doi.org/10.1016/j.vaccine.2003.07.013