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Effects of severe spasticity treatment with intrathecal Baclofen in multiple sclerosis patients: Long term follow-up.
- Source :
-
NeuroRehabilitation . 2016, Vol. 38 Issue 4, p385-393. 9p. 1 Chart, 4 Graphs. - Publication Year :
- 2016
-
Abstract
- BACKGROUND: Intrathecal Baclofen is available to treat severe generalized spasticity in Multiple Sclerosis (MS) unresponsive to oral drug delivery. OBJECTIVE: The aims of this study were to investigate the effects and the drug dosage of intrathecal Baclofen in a selected population of MS patients, affected by severe spasticity at long term follow-up. METHODS: A prospective cohort study of 14 MS patients is presented. Spasticity and pain were periodically assessed and the Baclofen dosage was adjusted. RESULTS: The initial Baclofen dosage was 136.2±109.3μg, then it was increased at 12 months to 228.6±179.2μg (p < 0.05). The subsequent dose adjustments did not result in significant changes up to 76 months. Spasticity on the lower limbs decreased significantly from pre-implantation assessment (median: 3.5, IQR: 3.0-4.0) to 12 months evaluation (median: 0.5, IQR: 0.0-2.0) (p < 0.001); no further decrease was observed after 24 months (median: 0.5, IQR: 0.0-1.5); when pain was present, it decreased. Some effects on cerebellar symptoms were observed. Botulinum toxin injections were used with intrathecal Baclofen therapy. CONCLUSIONS: A reduced spasticity and pain was observed after the intrathecal Baclofen infusion for at least 76 months. To obtain these results a dosage adjustment was needed only in the first year after the implantation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FUNCTIONAL assessment
*DRUG infusion pumps
*LONGITUDINAL method
*MULTIPLE sclerosis
*PROBABILITY theory
*SPASTICITY
*STATISTICS
*SURVIVAL
*T-test (Statistics)
*DATA analysis
*PAIN measurement
*TREATMENT effectiveness
*REPEATED measures design
*BACLOFEN
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
*SPINAL infusions
*ONE-way analysis of variance
Subjects
Details
- Language :
- English
- ISSN :
- 10538135
- Volume :
- 38
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- NeuroRehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 115899191
- Full Text :
- https://doi.org/10.3233/NRE-161329