An open randomized controlled clinical trial to evaluate ridge preservation and repair using Socket KAP™ and Socket KAGE™: part 2 - three-dimensional alveolar bone volumetric analysis of CBCT imaging.

Objectives The aims of this study were (i) to evaluate the efficacy of ridge preservation and repair procedures involving the application of Socket KAP™ and Socket KAGE™ devices following tooth removal and (ii) to evaluate alveolar bone volumetric changes at 6 months post-extraction in intact sockets or those with facial wall dehiscence defects using 3-dimensional pre- and postoperative CBCT data. Materials and Methods Thirty-six patients required 61 teeth extracted. Five cohorts were established: Group A: Intact Socket Negative Control Group B: Intact Socket + Socket KAP™ Group C: Intact Socket Filled with Anorganic Bovine Bone Mineral ( ABBM) + Socket KAP™ Group D: Facial Dehiscence Socket Negative Control Group E: Facial Dehiscence Socket Filled with ABBM + Socket KAP™ + Socket KAGE™. Preoperative CBCT scans were obtained followed by digital subtraction of the test teeth. At 6 months post-extraction, another CBCT scan was obtained. The pre- and postoperative scans were then superimposed, allowing highly accurate quantitative determination of the 3D volumetric alveolar bone volume changes from baseline through 6 months. Results Significant volumetric bone loss occurred in all sockets, localized mainly in the 0-3 mm zone apical to the ridge crest. For intact sockets, Socket KAP™ + ABBM treatment led to a statistically significant greater percentage of remaining mineralized tissue volume when compared to negative control group. A significant difference favoring Socket KAP™ + Socket KAGE™ + ABBM treatment was observed for sockets with facial dehiscence defects compared to the negative control group. Conclusions Socket KAP™, with ABBM, appears effective in limiting post-extraction volumetric bone loss in intact sockets, while Socket KAP™ + Socket KAGE + ABBM appears effective in limiting post-extraction bone loss in sockets with dehiscence defects. [ABSTRACT FROM AUTHOR]