Caracterización del compartimento leucocitario de los pólipos nasosinusales.

BACKGROUND: The nasosinusal polyposis is the result of a chronic inflammatory process characterized by a cellular infiltration of eosinophils, which collaborate often to pathologies such as asthma; nevertheless, other cellular types are also involved in its physiopathology as neutrophils which have different clinical behavior, being necessary specific treatments. OBJECTIVES: To describe and to characterize the leukocitary compartment in patients with nasosinusal polyposis of the National Institute of Respiratory Diseases of Mexico, and to identify cases of nasosinusal polyposis with neutrophil not syndromic predominance. MATERIAL AND METHOD: A retrospective, cross-sectional, observational and comparative study of absolute and percentage eosinophil and neutrophil quantification was made in samples obtained from 123 patients submitted to endoscopic surgery due to nasosinusal polyposis diagnosis. Clinical characteristics of patients with nasosinusal polyposis were identified by reviewing clinical records, splitting into 4 groups in accordance with histological characteristics and association to syndromes. RESULTS: 27 (22%) patients were identified with neutrophilic infiltration more than 60%; while 96 (78%) patients had eosinophilic predominance more than 60%. In the analysis of logistic regression statistical interrelation was not found between the quantity of eosinophils and neutrophils with the clinical recurrence (p=0.649 in the group with syndromic eosinophilic predominance and p=0.756 in the group with not syndromic neutrophilic predominance). CONCLUSIONS: There was not found statistical difference between the type of predominant leukocitary compartment respect to recurrence and presurgical endoscopic degree, which suggests that it is necessary to measure the proinflammatory factors. [ABSTRACT FROM AUTHOR]