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High cystatin C levels predict undesirable outcome for diabetic foot ulcerations.
- Source :
-
Wound Repair & Regeneration . May/Jun2016, Vol. 24 Issue 3, p560-567. 8p. - Publication Year :
- 2016
-
Abstract
- We investigated the relationship between serum cystatin C levels and the prognosis of diabetic foot ulcerations (DFU). A population-based cohort study involving 1018 patients with type 2 diabetes was conducted. These patients recruited and divided into two groups: nondiabetic foot ulcer group (NDF, n = 865, 85.5%) and diabetic foot ulcer group (DFU, n = 147, 14.5%).After a 1-year-follow-up, DFUs were grouped into healing ( n = 110, 74.8%) and nonhealing ( n = 37, 25.2%) group based on the clinical prognosis. Compared with the healing group, the nonhealing group were older, had long diabetic duration and had significantly increased serum cystatin C concentrations in DFU ( p < 0.01). After adjustments for age, diabetes duration, renal function and infection control, multiple logistical regression analysis revealed that cystatin C remained associated increased risk of undesirable DFU outcome (OR = 7.279, 95% CI: 1.299-40.784, p < 0.05). When divided into quartiles according to cystatin C levels, the healing rate of Quartile 4 was significantly lower (57.9%) compared with other groups ( p < 0.01). The odd is ratio (OR) analysis showed that the risk of undesirable DFU outcome in Quartile 4 was significantly higher (OR = 4.554, 95% CI: 3.14-5.12, p < 0.05) compared with that in Quartile 1. We concluded that there was a strong and independent association between serum cystatin C and diabetic foot ulceration prognosis, cystatin C > 1.35 mg/L predicts more than sixfold increased risk of incurable foot ulceration. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TYPE 2 diabetes complications
*ANALYSIS of variance
*LONGITUDINAL method
*PROTEINS
*RESEARCH funding
*STATISTICS
*T-test (Statistics)
*TIME
*DATA analysis
*MULTIPLE regression analysis
*DIABETIC foot
*PREDICTIVE tests
*RECEIVER operating characteristic curves
*DATA analysis software
*KRUSKAL-Wallis Test
Subjects
Details
- Language :
- English
- ISSN :
- 10671927
- Volume :
- 24
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Wound Repair & Regeneration
- Publication Type :
- Academic Journal
- Accession number :
- 115695008
- Full Text :
- https://doi.org/10.1111/wrr.12419