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Effects of moderate-intensity physical exercise on pharmacokinetics of factor VIII and von Willebrand factor in young adults with severe haemophilia A: a pilot study.
- Source :
-
Haemophilia . May2016, Vol. 22 Issue 3, pe177-e183. 7p. - Publication Year :
- 2016
-
Abstract
- Introduction In persons with severe haemophilia A (pwshA), infused factor VIII ( FVIII) half-life can vary according to such determinants as blood group, von Willebrand factor ( VWF) level or age; however, FVIII pharmacokinetics ( PK) has not been well studied in pwshA during exercise. Aim To investigate FVIII PK in pwshA performing moderate-intensity aerobic exercise. Methods Twelve young-adult pwshA with the intron-22 inversion mutation, on relatively low-dose FVIII prophylaxis regimens, and relatively good musculoskeletal status were recruited. Abbreviated PK of FVIII activity and von Willebrand factor antigen ( VWF:Ag) level were compared - during rest, and with 60-min exercise (2 × 15 min each of moderate-intensity stationary cycling and treadmill walking). During rest and exercise visits, a baseline blood specimen was drawn, routine prophylaxis FVIII infused; then six blood specimens were taken over the following 24 h. Results For all subjects, mean half-life of infused FVIII did not change significantly with exercise vs. at rest (577 ± 190 vs. 614 ± 163 min; P = 0.4131). VWF:Ag rose transiently by 40-50% for 6-8 h with exercise ( P < 0.01), particularly in non-O blood group subjects. No musculoskeletal bleeds occurred during the study. Conclusion Four × 15 min of moderate-intensity aerobic exercise increased VWF:Ag levels for 6-8 h, and showed no evidence of accelerated FVIII clearance or of musculoskeletal bleeding in these young-adult pwshA with relatively good musculoskeletal status, on relatively low-dose FVIII prophylaxis regimens. However, O blood group impact would merit larger studies, with longer durations of similar or more vigorous exercise intensities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13518216
- Volume :
- 22
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Haemophilia
- Publication Type :
- Academic Journal
- Accession number :
- 115460077
- Full Text :
- https://doi.org/10.1111/hae.12869