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Primary Low Level of High-Density Lipoprotein Cholesterol and Risks of Coronary Heart Disease, Cardiovascular Disease, and Death: Results From the Multi-Ethnic Study of Atherosclerosis.
- Source :
-
American Journal of Epidemiology . 5/15/2016, Vol. 183 Issue 10, p875-883. 9p. - Publication Year :
- 2016
-
Abstract
- Prior studies observing associations between low levels of high-density lipoprotein (HDL) cholesterol and cardiovascular disease (CVD) have often been conducted among persons with metabolic or other lipid abnormalities. In this study, we investigated the association between primary low HDL cholesterol and coronary heart disease (CHD), CVD, and all-cause death after adjustment for confounders in the Multi-Ethnic Study of Atherosclerosis (MESA). Participants who were free of clinical CVD were recruited from 6 US research centers from 2000 to 2002 and followed for a median duration of 10.2 years. We defined "primary low HDL cholesterol" as HDL cholesterol level <40 mg/dL (men) or <50 mg/dL (women), triglyceride level <100 mg/dL, and low-density lipoprotein cholesterol level <100 mg/dL (n= 158). We defined an "optimal" lipid profile as HDL cholesterol ≥40 mg/dL (men) or ≥50 mg/dL (women) and triglycerides and low-density lipoprotein cholesterol <100 mg/dL (n= 780). For participants with primary low HDL cholesterol versus those with an optimal lipid profile, adjusted hazard ratios for total CHD, CVD, and death were 2.25 (95% confidence interval (CI): 1.20,4.21; P= 0.011), 1.93 (95% CI: 1.11,3.34; P= 0.020), and 1.11 (95% CI: 0.67, 1.84; P=0.69), respectively. Participants with primary low HDL cholesterol had higher risks of CHD and CVD than participants with optimal lipid profiles but no difference in survival after a median 10.2 years of follow-up. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANGINA pectoris
*ATHEROSCLEROSIS complications
*ATHEROSCLEROSIS
*CARDIOVASCULAR disease diagnosis
*CORONARY heart disease risk factors
*HEART disease risk factors
*HYPERTENSION
*SMOKING
*HYPERLIPIDEMIA
*ADRENERGIC beta blockers
*ASPIRIN
*CHOLESTEROL
*CONFIDENCE intervals
*DIABETES
*CORONARY disease
*DOCUMENTATION
*ALCOHOL drinking
*CLINICAL drug trials
*EPIDEMIOLOGY
*ESTROGEN
*ETHNIC groups
*HIGH density lipoproteins
*LIPOPROTEINS
*LONGITUDINAL method
*LOW density lipoproteins
*NIACIN
*RACE
*RESEARCH funding
*TRIGLYCERIDES
*COMORBIDITY
*STATINS (Cardiovascular agents)
*DATA analysis
*BODY mass index
*LIFESTYLES
*HUMAN research subjects
*PATIENT selection
*PHYSICAL activity
*LABORATORY test panels
*CLOFIBRIC acid
*CONFOUNDING variables
*DIAGNOSIS
*GENETICS
MYOCARDIAL infarction diagnosis
MORTALITY risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 183
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 115359791
- Full Text :
- https://doi.org/10.1093/aje/kwv305