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Towards Increasing the Clinical Relevance of In Silico Methods to Predict Pathogenic Missense Variants.
- Source :
-
PLoS Computational Biology . 5/12/2016, Vol. 12 Issue 5, p1-16. 16p. - Publication Year :
- 2016
-
Abstract
- The author discusses the use of in silico methods for the prediction of pathogenic missense variants. Also tackled are topics on bioinformatics classifiers of phenotype, independent testing of cSNV variant classifiers and implications of variant classifier performance. Explored is the alternative and complementary framework of endophenotypes.
Details
- Language :
- English
- ISSN :
- 1553734X
- Volume :
- 12
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- 115293127
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1004725