Haemoglobinopathies among the tribal and non-tribal antenatal mothers in a tertiary care hospital of rural West Bengal, India.

Introduction: Anaemia in pregnancy is still a major concern in reducing maternal morbidity and mortality in India particularly in rural population. Haemoglobinopathies are important contributors to anaemia in pregnancy in rural India particularly in tribal population. Beta thalassemia is the commonest type of haemoglobinopathy all over the world. Thalassemia and other haemoglobinopathies are highly prevalent among the tribal communities in West Bengal. Bankura is one of the districts of West Bengal where more tribal population are present. So detection and prevention of thalassemias is one of the major public health problems in this part of the state of West Bengal.Study done by Manna et al4 showed that about 10% of the population is carrier of haemoglobin disorder.This study was taken up to document the recent prevalence status of hemoglobinopathies particularly Thalassemias and coexistence of iron deficiency anaemias Objective: To find out prevalence of haemoglobinopathies and to compare the prevalence of different types of Thalassemias among the antenatal mothers. Materials and Methods: This study was carried out in Bankura Sammilani Medical College (BSMC), Bankura West Bengal among 3500 tribal and non-tribal antenatal mothers. Cation exchange-high performance liquid chromatography (CE-HPLC) is being used for investigation for hemoglobinopathies and thalassemias. Together with a complete blood count, the CE-HPLC is effective in categorizing hemoglobinopathies as traits, homozygous disorders and compound heterozygous disorders. Results: In our study 275 mothers had haemoglobinopathy. The commonest disorder we encountered was Beta Thalassemia trait (57.5%), followed by HbE carrier (36%), homozygous HbE disease (1%), HbS carrier (4%), HbE Beta Thalassemia (1.5%). [ABSTRACT FROM AUTHOR]