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Response to transarterial chemoembolization as a selection criterion for resection of hepatocellular carcinomas.
- Source :
-
British Journal of Surgery . Jun2016, Vol. 103 Issue 7, p881-890. 10p. - Publication Year :
- 2016
-
Abstract
- Background Liver resection for intermediate (Barcelona Clinic Liver Cancer ( BCLC) stage B) hepatocellular carcinoma ( HCC) remains controversial. This study attempted to demonstrate the effectiveness of preresection transarterial chemoembolization ( TACE) as a selection criterion for BCLC-B HCC. Methods The study included patients with BCLC-B HCC who underwent liver resection after TACE. The tumour response to TACE was evaluated according to the modified Response Evaluation Criteria in Solid Tumours ( mRECIST). Patients with a complete or partial response comprised the responder group, whereas those with stable or progressive disease were classified as non-responders. Results A total of 242 patients were included. After between one and eight sessions of TACE, 141 patients were included in the responder group: 37 patients (15·3 per cent) who achieved a complete response and 104 who had a partial response. The cumulative 1-, 3- and 5-year overall survival rates were 97·2, 88·7 and 75·2 per cent respectively in the responder group, compared with 90·1, 67·3 and 53·5 per cent among 101 non-responders ( P < 0·001). Tumour-free survival rates were also better among responders than non-responders ( P < 0·001). In multivariable analysis, independent predictors of overall and tumour-free survival were response to TACE and microvascular invasion (all P < 0·001). Conclusion mRECIST may represent selection criterion for intermediate HCC for surgical treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHEMOEMBOLIZATION
*LIVER cancer
*HEPATECTOMY
*LIVER surgery
*PROGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00071323
- Volume :
- 103
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- British Journal of Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 115269945
- Full Text :
- https://doi.org/10.1002/bjs.9864