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PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol) augments the therapeutic effect of pegfilgrastim on gemcitabine-induced neutropenia.
- Source :
-
Cancer Letters . Jul2016, Vol. 377 Issue 1, p25-31. 7p. - Publication Year :
- 2016
-
Abstract
- Granulocyte colony-stimulating factor (G-CSF) is widely used for preventing neutropenia during chemotherapy. Polyethylene glycol-conjugated granulocyte colony-stimulating factor (PEG-G-CSF, pegfilgrastim) serves the same purpose but has a longer half-life and greater stability than G-CSF. In this study, we investigated whether 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride (PLAG), augments the therapeutic effect of pegfilgrastim on chemotherapy-induced neutropenia. We compared neutrophil counts in four groups of mice: control mice, gemcitabine-treated mice, gemcitabine/pegfilgrastim-treated mice, and gemcitabine/pegfilgrastim/PLAG-treated mice. PLAG (50 mg/kg) was orally administered every day during the treatment course. CBC analysis showed that the group treated with PLAG experienced a dramatically increased neutrophil counts on the third day following pegfilgrastim treatment. PLAG had no effect on blood cell apoptosis and neutrophil release from bone marrow. Additionally, pegfilgrastim-induced CXCR2 expression in neutrophils was markedly decreased in PLAG-treated animals. These results suggest that PLAG plays a role in inhibiting neutrophil extravasation, giving rise to an increased number of circulating neutrophils when used with pegfilgrastim during gemcitabine treatment. These data support the potential for PLAG to be used with pegfilgrastim to treat or prevent chemotherapy-induced neutropenia by modulating neutrophil transmigration. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GLYCERIN
*FILGRASTIM
*NEUTROPENIA
*DRUG therapy
*POLYETHYLENE glycol
*NEUTROPHILS
*LABORATORY mice
*BLOOD cell count
*PREVENTION
*ANIMAL experimentation
*BIOLOGICAL models
*CELL receptors
*CELL motility
*COMBINATION drug therapy
*COMPARATIVE studies
*DRUG synergism
*GLYCERIDES
*RESEARCH methodology
*MEDICAL cooperation
*MICE
*RECOMBINANT proteins
*RESEARCH
*TIME
*EVALUATION research
*DEOXYCYTIDINE
*LEUKOCYTE count
*BLOOD
Subjects
Details
- Language :
- English
- ISSN :
- 03043835
- Volume :
- 377
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Cancer Letters
- Publication Type :
- Academic Journal
- Accession number :
- 115243843
- Full Text :
- https://doi.org/10.1016/j.canlet.2016.04.025