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JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.
- Source :
-
Cancer Research . 5/1/20162016, Vol. 76 Issue 9, p2802-2812. 11p. - Publication Year :
- 2016
-
Abstract
- Substantial evidence links Myc-PI3K/AKT signaling to the most aggressive subtype of medulloblastoma and this axis in medulloblastoma therapy. In this study, we advance understanding of how Myc-PI3K/AKT signaling contributes to this malignancy, specifically, in identifying the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma. JPO2 overexpression induced metastatic medulloblastoma in vivo through two synergistic feed-forward regulatory circuits involving LEDGF/p75 and AKT that promote metastatic phenotypes in this setting. Overall, our findings highlight two novel prometastatic loci in medulloblastoma and point to the JPO2:LEDGF/p75 protein complex as a potentially new targetable component of PI3K/AKT signaling in medulloblastoma. Cancer Res; 76(9); 2802-12. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARRIER proteins
*MEDULLOBLASTOMA
*CELL communication
*METASTASIS
*PHENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 00085472
- Volume :
- 76
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 115175200
- Full Text :
- https://doi.org/10.1158/0008-5472.CAN-15-2194