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Concise Total Syntheses of Pyrido[4,3- b]carbazole Alkaloids Using Copper-Mediated 6π-Electrocyclization.
- Source :
-
European Journal of Organic Chemistry . May2016, Vol. 2016 Issue 13, p2290-2299. 10p. - Publication Year :
- 2016
-
Abstract
- Concise syntheses of 9-methoxyellipticine, 3,4-dihydroellipticine (µ-alkaloid D), 1,2,3,4-tetrahydroellipticine, 2-methyl-1,2,3,4-tetrahydroellipticine, olivacine, 3,4-dihydroolivacine, (±)-guatambuine, and (±)-janetine were developed starting from hexatriene intermediates readily obtained by Pd-catalyzed tandem cyclization/cross-coupling reaction of indolylborates. The route enables the facile construction of pyrido[4,3- b]carbazoles by Cu-catalyzed 6π-electrocyclization and subsequent transformation of the pyridocarbazole intermediates into pyrido[4,3- b]carbazole alkaloids. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 2016
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 115131195
- Full Text :
- https://doi.org/10.1002/ejoc.201600246