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Cutting Edge: The RIG-I Ligand 3pRNA Potently Improves CTL Cross-Priming and Facilitates Antiviral Vaccination.
- Source :
-
Journal of Immunology . 3/15/2016, Vol. 196 Issue 6, p2439-2443. 5p. - Publication Year :
- 2016
-
Abstract
- Protective immunity against intracellular pathogens involves the induction of robust CTL responses. Vaccination with protein Ags establishes such responses only when combined with immune-stimulatory adjuvants. In this study, we compared different adjuvants and identified triphosphate RNA (3pRNA) as especially effective at inducing CTL responses. 3pRNA sensing required IPS-1/MAVS signaling and induced type I IFN in plasmacytoid dendritic cells and macrophages, with the latter being more important for the adjuvant effect. Type I IFN acted on CD11c+ cells, especially on CD8α+ Batf3-dependent dendritic cells. Vaccination with OVA in combination with 3pRNA protected mice from a subsequent OVA-encoding adenovirus infection in a CD8+ cell-dependent manner and more efficiently than other adjuvants. In summary, 3pRNA is a superior adjuvant for CTL activation and might be useful to facilitate antiviral immunization strategies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTRACELLULAR pathogens
*IMMUNITY
*DENDRITIC cells
*VACCINATION
Subjects
Details
- Language :
- English
- ISSN :
- 00221767
- Volume :
- 196
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 114939544
- Full Text :
- https://doi.org/10.4049/jimmunol.1501958