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Association of overexpression of p53 oncoprotein with the state of cell proliferation in oral carcinoma.
- Source :
-
Journal of Oral Pathology & Medicine . Jul1994, Vol. 23 Issue 6, p246-250. 5p. - Publication Year :
- 1994
-
Abstract
- p53 is a nuclear phosphoprotein recognised as important in the regulation of normal cell growth and proliferation, the wild-type protein suppressing cell division. Expression of presumptive mutant protein, detected by immunohistochemistry, is used increasingly as a diagnostic and prognostic marker in human neoplasms. A question arises as to whether or not p53 (over)expression in a lesion is any more or less informative than other markers of cell proliferation. Twenty well-differentiated oral squamous cell carcinomas which had earlier been examined for immunoreactivity against a panel of p53 antibodies were examined for the status of cell proliferation--both in islands of invading neoplastic cells and in the non-malignant epithelial margins. The status of epithelial cell proliferation was found to be significantly higher in p53-positive tumours when enumerated by Ki-67 antibody, both within the tumour as well as its margins. This may confer a growth advantage to these neoplasms and reflect a status of inactivated p53 protein, although the actual cause of the rapid proliferation may lie in activation/inactivation of other genes. The PCNA labelling indices, on the other hand, were closely similar in both p53-positive and -negative groups, suggesting that stabilisation of p53 protein does not influence the proliferative advantage in these carcinomas via a deregulation step of PCNA-related gene products. [ABSTRACT FROM AUTHOR]
- Subjects :
- *P53 protein
*CELL proliferation
*ORAL cancer
*IMMUNOHISTOCHEMISTRY
Subjects
Details
- Language :
- English
- ISSN :
- 09042512
- Volume :
- 23
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Oral Pathology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 11476268
- Full Text :
- https://doi.org/10.1111/j.1600-0714.1994.tb00053.x