Repeat transurethral resection for non-muscle-invasive bladder cancer: a contemporary series.

Objectives To evaluate the depth of transurethral resections of bladder tumour ( TURBT), residual cancer rates and up-staging rates in a contemporary Australian series. Materials and Methods Specimen reports from a single, major reporting pathology centre, servicing a group of urological oncologists in Sydney were obtained for TURBTs performed between October 2008 and February 2013. We examined the depth of TURBT, rates of repeat- TURBT (re- TUR) and residual cancer rates at the 3-6 month check cystoscopy. Results One thousand and two hundred and nine transurethral resection specimens retrieved during this period were analysed. There were 162 (13.4%) T1 specimens and 631 (52.2%) Ta specimens, 218 (34.5%) of which were high grade. Muscularis propria was present in 506 (41.9%) specimens in total and in 151 (39.7%) of 380 high-risk specimens (high grade Ta, T1). Of the 380 high-risk non-muscle-invasive tumours, 85 (22.4%) proceeded to re- TUR. Of the 48 T1 specimens and 37 Ta high grade specimens that proceeded to re- TUR, 7 (14.6%) and 1 (2.7%) respectively were upstaged to muscle-invasive disease. Rates of residual disease/early recurrence at 3-6 months was significantly better for those with re- TUR compared to those without 56.8% vs 82.5% ( P < 0.001) for Ta high grade and 39.6% vs 84% ( P = 0.028) for T1 tumours respectively. Conclusion Re- TUR rates in high-risk non-muscle-invasive bladder cancer are low. However in a contemporary series, the upstaging rates are low, but residual cancer rates high, supporting the need for re- TUR in this population. [ABSTRACT FROM AUTHOR]