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Pulmonary resident neutrophils regulate the production of GM- CSF and alveolar macrophages.
- Source :
-
FEBS Journal . Apr2016, Vol. 283 Issue 8, p1465-1474. 10p. - Publication Year :
- 2016
-
Abstract
- Alveolar macrophages exist in the lung airspaces, and their differentiation and function are considerably regulated by the microenvironment. In this study, we examine the important role of resident neutrophil/ IL-23/granulocyte/macrophage colony-stimulating factor ( GM- CSF) axis in the development and preferential phenotype of alveolar macrophages under physiological conditions. Using CD18-deficient ( CD18 −/−) mice, we show a correlation between increased granulopoiesis and enhanced alveolar macrophage development in an IL-23- and GM- CSF-dependent manner. The apoptotic neutrophils could inhibit the secretion of IL-23 from alveolar macrophages, which is important for the production of GM- CSF, and depletion of neutrophils disrupted the regulation of IL-23 and GM- CSF. This study reveals a mechanism for the regulation of the local alveolar macrophage population and function by neutrophil apoptosis in the circulatory system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1742464X
- Volume :
- 283
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- FEBS Journal
- Publication Type :
- Academic Journal
- Accession number :
- 114603783
- Full Text :
- https://doi.org/10.1111/febs.13684