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Yeast-containing feed additive alters gene expression profiles associated with innate immunity in whole blood of a rodent model.
- Source :
-
Innate Immunity . May2016, Vol. 22 Issue 4, p249-256. 8p. - Publication Year :
- 2016
-
Abstract
- Feeding a yeast-containing additive (YCA; OmniGen-AF) improves immune responses in ruminant livestock and reduces subsequent production losses. The objective was to identify molecular pathways by which dietary YCA may modify immune responses using a rodent model. Thirty-seven healthy, unchallenged CD rats received a diet containing 0 (control; n = 5, only 28 d), 0.5% (n = 15) or 1% (n = 17) YCA for 7 (n = 4/group), 14 (n = 3 or 4/group), 21 (n = 3 or 4/group) or 28 (n = 5/group) d. At the end of the feeding periods, whole blood was collected and the isolated RNA was analyzed for the expression of 84 genes involved in innate and cell-mediated adaptive immune responses. Three bacterial pattern recognition receptors TLR1 (0.5%: + 2.01; 1%: + 2.38), TLR6 (0.5%: + 2.11; 1%: + 2.34) and NOD2 (0.5%: + 2.32; 1%: + 2.23), two APC surface receptors CD1D1 (0.5%: + 1.75; 1%: + 2.33) and CD80 (0.5%: +2.45; 1%: +3.00), and the cell signaling molecule MAPK8 (0.5%: +1.87; 1%: +2.35) were significantly up-regulated by YCA at both inclusion rates. In conclusion, feeding YCA may potentially increase recognition and responses to bacterial pathogens and T-cell activation and differentiation and thereby maintain health and prevent production losses. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17534259
- Volume :
- 22
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Innate Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 114575391
- Full Text :
- https://doi.org/10.1177/1753425916640326